Polyethylene glycol (PEG): A polymer used in Moderna’s mRNA-1273, it seems it can be microwave-accelerated?

 

The idea of microwave acceleration in medicine or microwave-accelerated is fast becoming a new and novel way of dealing with internal medicine without surgery.

Polyethylene glycol, a polymer used in the new mRNA-1273 vaccine of Moderna can be, microwave-accelerated. Meaning that you can use 5G technology to interact with it, activate it or de-activate it.

You could wrap a piece of mRNA in Polyethylene glycol (PEG) — PEGxylation, and that polymer, through vaccine injection is carried into the cells, microwave acceleration releases/activates/deactivates the nano-particles; genetic material, nanotechnology or sensor.

For years ultrasound has been used to gain an image of a fetus in development within a womb. Microwave-accelerated and delivery of cancer therapeutics without invasive surgery has gone on for some time now also.

WiFi’ed is a term coined on everything from soup to nuts. From library books to WiFi’ed connection to products within the area of the store to protect against shop-lifting.

 

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But what about within medicine. Say a WiFi’ed drug for sex offenders. Or a court-ordered psychotropic for a schizophrenic. Or proof of vaccine, or even its activation.

5G and the IoT (Internet of Things) is bound to explode the world we live in with connection to all kinds of “things”. It promises to connect everything within the world of the IoT.

Microwave energy has been used in the treatment of type 2 diabetes. The drug Glipizide is an anti-diabetic medication that is not water-soluble. In a comparative study

Microwave-generated bionanocomposites for solubility and dissolution enhancement of poorly water-soluble drug glipizide: in-vitro and in-vivo studies -Sachin Shivaji Kushare 1Surendra G Gattani

Objectives: In oral absorption of a drug, the drug first dissolves and then is absorbed by diffusion through gastrointestinal membranes. The gastrointestinal environment is aqueous in nature and it is well-known that one-third of the drug population is water-insoluble. Hence, there is a need for enhancement of the solubility and dissolution of such drugs. In this work, enhancement of the solubility and dissolution of the practically insoluble drug glipizide was achieved by formation of bionanocomposites (BNCs) using microwave-induced diffusion (MIND), which ultimately leads to bioavailability enhancement.
In another study in ScienceDirect, the International Journal of Pharmaceutics Volume 573, January 5th, 2020

Dendrimers in the context of nanomedicine – Ana PaulaDiasaSorayada Silva SantosaJoão Vitorda SilvaaRobertoParise-FilhoaElizabethIgne FerreiraaOmar ElSeoudbJeanineGiarollaa

Dendrimers are globular structures, presenting an initiator core, repetitive layers starting radially from the core and terminal groups on the surface, resembling tree architecture. These structures have been studied in many biological applications, as drug, DNA, RNA and proteins delivery, as well as imaging and radiocontrast agents. With reference to that, this review focused in providing examples of dendrimers used in nanomedicine. Although most studies emphasize cancer, there are others which reveal action in the neurosystem, reducing either neuroinflammation or protein aggregation. Dendrimers can carry bioactive compounds by covalent bond (dendrimer prodrug), or by ionic interaction or adsortion in the internal space of the nanostructure. Additionally, dendrimers can be associated with other polymers, as PEG (polyethylene glycol), and with targeting structures as aptamers, antibodies, folic acid and carbohydrates. Their products in preclinical/clinical trial and those in the market are also discussed, with a total of six derivatives in clinical trials and seven products available in the market.

Dendrimers are repetitively branched molecules, dendritic molecules that can be used in drug delivery, like brain drugs. Dendrimers can take advantage of being able to cross the blood-brain barrier so easily, and in that, they are very advantageous…

Starpharma, an Australian pharmaceutical company, has multiple products that have either already been approved for use or are in the clinical trial phase. SPL7013, also known as astodrimer sodium, is a hyperbranched polymer used in Starpharma’s VivaGel line of pharmaceuticals that is currently approved to treat bacterial vaginosis and prevent the spread of HIV, HPV, and HSV in Europe, Southeast Asia, Japan, Canada, and Australia. Due to SPL7013’s broad antiviral action, it has recently been tested by the company as a potential drug to treat SARS-CoV-2. The company states preliminary in-vitro studies show high efficacy in preventing SARS-CoV-2 infection in cells.

Dendrimers can be used in gene delivery and transfection ( infection of a cell with an isolated viral nucleic acid followed by the production of the complete virus in the cell) of cells with a known virus. Dendrimers are looked at as a means of delivering pieces of DNA and/or RNA, mRNA using a water-soluble polymer, like a Polyethylene glycol (PEG).

It does this all through being masked to the host’s immune system and through PEGxylation.

PEGxylation is an exponentially, growing technology that is fast becoming the cutting edge treatment for kinds of ailments, and it is injectable and therein claims to lessen invasive surgery, but is safe?

Protein PEGylation: An overview of chemistry and process considerations

The above-linked article speaks to this.

Innovative drug delivery technologies are key components of drug development, with commercial and intellectual values. PEGylation is an excellent example of a delivery system that has scientific and multi-billion dollar commercial importance due to the remarkable improvement in the circulatory half lives of therapeutics, especially for proteins and peptides but even for small molecule pharmaceuticals. Beginning with a brief introduction to the pharmaceutical advantages of PEGylated therapeutics, the authors review the development of this technology over the past four decades in terms of conjugation chemistry, poly(ethylene glycol) structure and process considerations, and conclude that improved, versatile and generic production methods are required to meet the growing demands of the pharmaceutical market.

it concludes by stating…

Nearly four decades of development in PEGylation technology has proven its pharmacological advantages and acceptability but the technology still lags in providing a commercially attractive, generic process to produce highly specific PEGylated therapeutic products at high yield. As a multi-million dollar annual business with the growing interest from both emerging biotechnology and established multinational pharmaceutical companies, there is great scientific and commercial interest in improving present methodologies and in introducing innovative process variations.

Maybe this is why Bill Gates is sinking so many $Billions of dollars into new and state-of-the-art vaccine facilities around the globe.

And PEG is the polymer of choice. It is the polymer of choice for gene-editing, and cell transfection, the new mRNA-1273 has PEGxylated piece of messenger RNA that it carries into cells.

In fact, Polyethylene glycol (PEG) is a very common modification for Dendrimers in the case of gene delivery. The surface charge can be modified and thus the circulation time controlled more. I suspect 5G technology would be used in the control of that…

PEGxylated nanoparticles can be delivered with Dendrimers, nanoparticles that are mono-metallic, bimetallic and even semiconductor nano-particle…materials that would prove that a vaccine was administered to a host.

Dendrimers can be used as sensors as in an immunity passport. Things like Palladium, gold and very small 5G sensitive devices.

And in using a microwave-accelerated polymer like Polyethylene glycol (PEG) in this action. A 5G accelerated PEG.

This is highly unstable technology, that can have detrimental effects on kidneys and the whole health of the host. PEGxylation reactions times and conditions of the host, ph, temperature and underlying conditions unknown will have effects on this technology. The body could clear this technology without it performing its task, this is all dependent on the host and their general health, it all seems like a pure experiment on the population at large without any truly in-depth study of this technology.

The mRNA-1273 will be the first gene-editing, a gene-driving vaccine to date.

 

 

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